Selected Publications: 1.Malnassy, G., Keating C, Gad, S., Bridgeman B, Perera, A., Hou W., Cotler S., Ding X.Z., Choudhry M., Sun Z.L., Koleske A., Qiu, W. (2023) Inhibition of Abelson Tryrosine Protein Kinase 2 suppresses the development of alcohol-associated liver disease by decreasing PPARgamaa expression. Cell Mol Gastroenterol Hepatol. 2023 Jul.15. PMID: 37460041.
2. Hou W, Bridgeman B, Malnassy G, Ding XZ, Dhanarajan A, Cotler SJ, Qiu W. (2022) Integrin subunit beta 8 (ITGB8) contributes to lenvatinib resistance in hepatocellular carcinoma. Hepatology Communication. 2022 March 3. PMID: 35238496.
3. Wang H, Hou W, Perera A, Bettler C, Beach JR, Ding XZ, Li J, Denning MF, Dhanarajan A, Cotler SJ, Joyce C, Yin J, Ahmed F, Roberts LR, Qiu W. (2021) Targeting EphA2 Suppresses Hepatocellular Carcinoma Initiation and Progression by Dual Inhibition of JAK1/STAT3 and AKT signaling. Cell Reports. In press. 2021, Feb 23;34 (8):108765. PMID: 33626345.
4. Song XH, Xu HW, Wang P, Wang JX, Affo S, Wang HC, Xu M, Liang BY, Che L, Qiu W, Schwabe FS, Chang TT, Vogl M, Pes MG, Ribback S, Evert M, Chen X, Calvis FD. (2021) Focal Adhesion Kinase (FAK) promotes cholangiocarcinoma development and progression via YAP activation. Journal of Hepatology. May 27, 2021. S0168-8278(21)00353-6. PMID: 34052254.
5. Chen Y, Li Q, Tu K, Wang Y, Wang X, Liu D, Chen C, Liu D, Yang R, Qiu W, Kang N. Focal Adhesion Kinase Promotes Hepatic Stellate Cell Activation by Regulating Plasma Membrane Localization of TGFβ Receptor 2. Hepatology Communication. 2019. Dec 20;4(2):268-283. PMID: 32025610.
6. Fang Wang, Wei Hou, Lennox Chitsike, Yingchen Xu, Carlee Bettler, Aldeb Perera, Thomas Bank, Scott J. Cotler, Asha Dhanarajan, Mitchell F. Denning, Xianzhong Ding, Peter Breslin, Wenan Qiang, Jun Li, Anthony J. Koleske and Qiu W. ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice. Gastroenterology. 2020, PMID: 31171747.
7. Pulido I, Ollosi S, Aparisi S, Becker JH, Aliena-Valero A, Benet M, Rodríguez ML, López A, Tamayo-Torres E, Chuliá-Peris L, García-Cañaveras JC, Soucheray M, Dalheim AV, Salom JB, Qiu W, Kaja S, Alcácer Fernández-Coronado J, Alandes S, Alcácer J, Al-Shahrour F, Borgia JA, Juan O, Nishimura MI, Lahoz A, Carretero J, Shimamura T. Endothelin-1-mediated Drug Resistance in EGFR-mutant NSCLC Cancer Res. Aug 3 2020. PMID: 32747363
8. Shang N#, Wang H#, Bank T, Perera A, Joyce C, Kuffel G, Michael Z, Cotler S, Ding XZ, Dhanarajan A, Breslin P,Qiu W. (2019) FAK and β-catenin cooperate to induce hepatocellular carcinoma.Hepatology. 2019, May 9. PMID: 31069844. (#, co-first authorship)
9.Shang, N., Bank, T., Ding, XZ., Breslin, P., Li, J., Shi, BM., Qiu, W. (2018) Caspase-3 suppresses diethylnitrosamine-induced hepatocyte death, compensatory proliferation and hepatocarcinogenesis through inhibiting p38 activation. Cell Death & Disease. 2018 9 (5), 558-568. PMID:29752472. PMCID: PMC5948202.
10.Wang, F., Bank, T., Arteaga, M., Shang, N., Dalheim, A., Ding, XZ., Colter, S., Denning., M., Nishimura, M., Breslin, P., Qiu, W. (2018) Inhibition of IGF1R enhances the efficacy of sorafenib in inhibiting HCC cell growth and survival. Hepatology Communication. 2018, Apr. 2 (6), 732-746. PMID: 29881824.
11.Chitsike, L., Ding, XZ., Breslin, P., Qiu, W.. ABL1 is Overexpressed and Activated in Hepatocellular Carcinoma. Journal of Cancer and Tumor International. 2017 6(3), 1-8.
12.Arteaga, M., Shang, N., Ding, X.Z., Yong, S., Cotler, S.J., Denning, M.F., Shimamura, T., Breslin, P., Bernhard, L., Qiu, W. (2016) Inhibition of SIRT2 suppresses hepatic fibrosis. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2016 Apr. 28. Epub ahead of print. PMID: 27125275.
14.Shang, N., Arteaga, M., Zaidi, A., Cotler, S.J., Breslin, P., Ding, X.Z., Kuo, P., Nishimura, M., Zhang, J., Qiu, W. (2016) FAK kinase activity is required for the progression of c-Met/β-catenin-driven HCC. Gene Expression: The journal of Basic Liver Research. 2016 May. 2. Epub ahead of print. PMID: 27142958
15.Shang, N., Arteaga, M., Zaidi, A., Stauffer, J., Cotler, S.J., Zeleznik-Le, N., Zhang, J., Qiu, W. (2015) FAK is required for c-Met/β-catenin-driven hepatocarcinogenesis. Hepatology. 2015 Jan. 61(1):214-26. PMID: 25163657.
16.Leibowitz B, Qiu W, Buchanan ME, Zou F, Vernon P, Moyer MP, Yin XM, Schoen RE, Yu J, Zhang L. (2014) BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16520-5. PMID: 25368155.
17.Qiu, W., Wang, X., Buchanan M., He, K., Zhang, L., Wang, Q. and Yu, J. (2013) ADAR1 is essential for intestinal homeostasis and stem cell maintenance. Cell Death Dis. Apr 18;4:e599. PMID: 23598411.
18.Qiu, W., Liu, H., Sebastini, A., Wang, H., Zhang, L. and Yu, J. (2012) An apoptosis-independent role of SMAC in tumor suppression. Oncogene. Jul 2. doi: 10.1038/onc.2012.265. [Epub ahead of print]
19.Bista, R.K., Uttam, S., Hartman, DJ., Qiu, W., Yu, J., Zhang, L., Brand, R.E. and Liu, Y. (2012) Investigation of nuclear nano-morphology marker as a biomarker for cancer risk assessment using a mouse model. J. Biomedical Optics 17, 066014, DOI:10.1117/1.JBO.17.6.066014
20.Qiu, W., Wang, X., Leibowitz, B., Yang, W.C., Zhang, L., and Yu, J. (2011) Loss of PUMA suppresses chemical hepatocarcinogenesis in mice. Hepatology. Jul 2. doi: 10.1002/hep.24516. [Epub ahead of print]
21.Dirisina, R., Katzman, R.B., Goretsky, T., Managlia, E., Mittal, N., Williams, D.B., Qiu, W., Yu, J., Chandel, N.S., Zhang, L. and Barrett, T.A. (2011) p53 and PUMA independently regulate intestinal epithelial cell apoptosis in colitis. Gastroentrology. May 27. [Epub ahead of print]
22.Leibowitz, B., Qiu, W., Liu, H., Cheng, T., Zhang, L., and Yu, J. (2011) Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21. Molecular Cancer Research. 9:619-25.
23.Qiu, W., Wu, B., Wang, X., Buchanan, M.E., Regueiro, M.D., Hartman, D.J., Schoen, R., Yu, J. and Zhang, L (2011). PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice. Journal of Clinical Investigation, 121: 1722–32.
24.Wang, P., Bista, R., Khalbuss, W., Qiu, W., Zhang, L., Brentnall, T.A., Brand, R. and Liu, Y. (2010) Nanoscale nuclear architecture for cancer diagnosis beyond pathology via spatial-domain low-coherence quantitative phase microscopy. Journal of Biomedical Optics 15(6), 066028.
25.Qiu, W., Wang, X., Leibowitz, B., Liu, H., Barker, N., Okada, H., Oue, N., Yasui, W., Clevers, H., Schoen, R., Yu, J. and Zhang, L. (2010) Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. Proc. Natl. Acad. Sci. USA. 107(46): 20027-32.
26.Qiu, W., Leibowitz, B., Zhang, L., and Yu, J. (2009) Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis. Oncogene 29: 1622–32.
27.Qiu, W., Carson-Walter, E.B., Kuan, S.F., Zhang, L., Yu, J. (2009). PUMA suppresses intestinal tumorigenesis in mice. Cancer Res. Jun 15; 69(12):4999-5006. Epub 2009 Jun 2.
28.Wang, P., Qiu, W., Dodgeon, C., Liu, H.T., Huang, C.S., Zambetti, G.P., Yu, J., Zhang, L (2009). PUMA is directly activated by NF-κB and required for TNF-α-induced apoptosis in vitro and in vivo. Cell Death Differ. 16(9):1192-202.
29.Qiu, W., Carson-Walter, E.B., Liu, H., Epperly, M., Greenberger JS, Zambetti GP, Zhang L, Yu J (2008). PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell. 2(6):576-83.
30.Wu, B., Qiu, W., Wang, P., Yu, H., Cheng, T., Zambetti, G.P., Zhang, L., Yu, J. (2007). p53-independent Induction of PUMA Mediates Intestinal Apoptosis in Response to Ischemia Reperfusion. Gut. 56(5):645-54.